of Characteristics of aging That’s exactly the feature. Although these are not intended to be a list of causal mechanisms, some may take them as such, especially if they assist in the selection of research and development programs. Some of the characteristics of aging are Strategies for artificially negligible aging (SENS) A list of proposed causal mechanisms of aging, the signature paper itself clearly contributes significantly to early SENS publications and parallel proposals such as the seven pillars of aging. When it comes to aspects of aging, it is important to focus on the cause rather than the effect, as only treating the cause is likely to be effective. The field calls for a broader and more high-profile critique and consideration of the characteristics of aging, with a view to identifying causal mechanisms for intervention rather than simply explaining aging.
In a recent review article, researchers conducted a thorough literature review and explained: Updated 12 characteristics of aging. Modern aging models comprehensively capture key features of the aging phenotype and incorporate new pathways that play important roles in aging-related processes. Although modern features of aging provide a useful framework for explaining aging phenotypes, aging itself is the result of mechanistically complex and interrelated processes that occur during the lifespan of an organism. Here I focus from a systematic description and classification of the hallmarks of aging to a model that separates the early molecular origins of changes from cellular and tissue reactions and represents the continuous and causal features of aging changes. I suggest moving the . The proposed model aims to stimulate discussion among the aging research community, guide future efforts in this field, and provide new ideas for investigation.
time 9 characteristics of original aging Although it was first introduced in 2013, little was known about the mechanisms of aging. Since then, many research groups have explained the different mechanisms underlying this process and introduced the concepts of the continuous nature of time variation and the molecular basis of the process. Therefore, I believe that aging features would benefit from including information on the temporal and continuous nature of the aging process. The aging process is generally divided into early and late events, and there is a clear distinction between aging and aging. Phenotype and the underlying molecular events. Aging involves molecular, physiological, and phenotypic changes that have different clinical relevance and different short- or long-term outcomes when aimed at pharmacological intervention. Therefore, I propose a “three-wheeled gear” model that describes early (upstream), intermediate, and late (downstream) events.
All kinds of stress/disorders can be induced epigenetic change, transcription noisenuclear DNA damage and mitochondrial DNA damage; cell membrane sincerity, and oxidative stress, among other molecular disorders. Intermediate events of aging include cellular responses to stress-induced molecular changes and include activation of inflammation. proteostasis, autophagy, agingestablished energy homeostasisand rewiring cell metabolism. If unresolved, repeated stress-induced molecular and cellular changes throughout an individual’s lifetime trigger late events of aging, manifesting as an aging phenotype. Late events of aging result in a progressive decline in organ function, leading to stem cell depletion, organ dysfunction, loss of tissue integrity, immune system dysfunction, including chronic low-level inflammation, and inter-tissue interactions. This includes changes in cell action and intercellular communication. . The molecular, cellular, and phenotypic processes of aging are interconnected, and the progression of one process induces the progression of all others.
Currently, investigational therapeutic approaches targeting the aging phenotype are primarily directed at reversing aging symptoms rather than targeting the underlying molecular or cellular mechanisms. However, recognizing the aging phenotype is important for deciphering the mechanisms underlying aging and age-related diseases. Complex biological processes such as aging cannot be fully delineated without addressing the molecular and cellular mechanisms that contribute to the various hallmarks of aging and dissecting the temporal and causal order of events. .